A New Method for the Determination of Amisulpride in a Small Volume (200 ?L) of Human Saliva Using LC-DAD Supported by SPE

(1) Background: The concentration of amisulpride, an atypical antipsychotic drug, is most often determined in the blood, with many inconveniences. An alternative may be to use saliva as a diagnostic material for this purpose. development method determine amisulpride using small volume biological could significantly improve patient comfort during Therapeutic Drug Monitoring (TDM). (2) Methods: Therefore, aim study was develop 200 ?L solid-phase extraction isolation and liquid chromatography diode array detector (LC-DAD) quantitative analysis. (3) Results: validated by determining its linearity range 5–500 ng/mL (R2 > 0.99), intra- inter-day precision expressed coefficient variation (CV%) did not exceed 9%. (4) Conclusions: developed used salivary patients treated studied compound, confirming usefulness TDM.